42GASTRO RETENTIVE DRUG DELIVERY SYSTEMSManagement of illness through medication is entering a new era in which growing number of Novel drug delivery systems are being employed and are available for therapeutic use. Oral sustained release gastro-retentive dosage forms (GRDFs) offer many advantages for drugs with absorption from upper parts of gastrointestinal tract and for those acting locally in the stomach, improving the bioavailability of the medicationkhidiragab@yahoo.comReview422014Novel drug delivery system,Gastro-retentive Dosage Forms,Sustained ReleaseKhidir Agab Mohammed HassanFaculty of Pharmacy, Northern Border University, Arar, Saudi Arabia