7TECHNOLOGICAL DEVELOPMENT AND STABILITY STUDY OF DIVALPROEX SODIUM EXTENDED RELEASE TABLETSThe behavior of different technological variants of extended release tablets of divalproex Sodium (960mg) obtained by direct compression technique. The extended time and the percentage of the dissolved drug showed a significant dependence of the polymers ratios present in formulae. The physical and chemical properties of tablets were assessed during 3 months (accelerated stability), respectively. From the formulae selected it was possible to obtain granulates and tablets with organoleptic, physiochemical and technological properties, demonstrating the feasibility of the process of fabrication of this product. Results showed the good stability in the extended release divalproex Sodium tablets selected. The in vitro dissolution hasn't significant differences, thus, neither the time elapsed nor the composition of formula influenced on the percentages of dissolved drug. The assessment demonstrated significant differences, however, assessed formulae fulfilled with official pharmaceutical specifications during 3 monthsjeganaths@gmail.comResearch212012Divalproex sodium,Hydroxyl Propyl Methyl Cellulose, Extended release,Direct compression technique,Stability studiesS. Jeganath, K. Senthil kumaran,V. Ashlin Viji,K. Sheeja DeviDepartment of pharmaceutics, K.K. College of pharmacy, Chennai, Tamilnadu, India,Department of pharmaceutics, K.K. College of pharmacy, Chennai, Tamilnadu, India,Department of Pharmaceutics, Periyar College of Pharmaceutical sciences, Trichy, Tamilnadu, India,Department of Pharmaceutical chemistry, KMCH college of Pharmacy, Coimbatore, Tamilnadu, India