34FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF GRANISETRON HYDROCHLORIDEOral drug delivery has been known for decades as the most widely utilized route of administration among all the routes that have been explored for the systemic delivery of drugs via various pharmaceutical products of different dosage forms. Dysphagia is a common problem encountered in all age groups in concern to solid dosage forms. To solve the problem of dysphagia and improve patient compliance, mouth dissolving tablets have emerged as an alternative to conventional oral dosage forms. In the present work, Orodispersible tablets of Granisetron Hydrochloride were designed with a view to enhance patient compliance by direct compression and sublimation methods. . In the direct compression method, Crosspovidone (4,5%w/w), crosscarmellose sodium (4,5% w/w), sodium starch glycollate (4,5%w/w) super disintegrants were used along with directly compressible microcrystalline cellulose to enhance mouth feel and in sublimation method these above mentioned super disintegrants along with urea are used . The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and In vitro dispersion time. All formulations were tested for In vitro drug release pattern (in phosphate buffer), Short-term stability (40ºc±2ºc/75%±5ºc RH for 3 months) and drugExcipient interaction study (IR spectroscopy). Among all the formulations, the formulation F8 prepared by Crosspovidone and urea by sublimation method found to have minimum dispersion time (7.33 s) and more drug release(99.28%) dineshkmr.pharma@gmail.comResearch412014Crosspovidone,Crosscarmellose sodium,Sodium Starch Glycolate,Urea,Granisetron hydrochloride,Orodispersible tabletsDinesh G,Kumar B,Gnanaprakash K,Gobinath M,Pradeepkumar CH,Vidyasagar NDepartment of Pharmaceutics, Ratnam Institute of Pharmacy, SPSR Nellore, Andhra Pradesh, India-524346,Department of Pharmaceutics, Ratnam Institute of Pharmacy, SPSR Nellore, Andhra Pradesh, India-524346,Department of Pharmaceutics, Ratnam Institute of Pharmacy, SPSR Nellore, Andhra Pradesh, India-524346,Department of Pharmaceutics, Ratnam Institute of Pharmacy, SPSR Nellore, Andhra Pradesh, India-524346,Department of Pharmaceutics, Ratnam Institute of Pharmacy, SPSR Nellore, Andhra Pradesh, India-524346,Department of Pharmaceutics, Ratnam Institute of Pharmacy, SPSR Nellore, Andhra Pradesh, India-524346