33FORMULATION AND EVALUATION OF TAPENTADOL IMMEDIATE RELEASE TABLETSImmediate release tablets are gaining popularity over conventional tablets due o their convience in administration and suitability for patients. The purpose of this research was o mask the intensely bitter taste of Tapentadol and to prepare immediate release tablets for achievement of quick onset of action of the drug. Tapentadol is an analgesic which has been proved to be efficient in managing relief from pain and including pa n after surgery. In the present study an attempt has been made to prepare bitterless immediate release tablet of Tapentadol using Eudragit E 100 as a taste masking agen . Mass extrusion was the technique used for preparing taste masked granules and tablet was prepared with using superdisintegrants like sod um starch glycolate, hydroxy propyl cellulose (L-HPC) and Microcrystalline cellulose (Avicel PH 102) were prepared blend and evaluated for the pre-compression parameters such as bulk density, compressibility, angle of repose etc. The prepared batches of tablets were evaluated for hardness, weight variation, friability, drug content, disintegration time and n-v ro dissolution profile and found satisfactory. Among the formulations containing sod um starch glycolate was least and tablets showed fastest disintegration. The drug release from orally d s n egra ng tablets increased with increasing concentration of superdisintegrants and was found to be h ghes with formulations containing sod um starch glycolate. Thus results conclusively demonstrated successfu masking of taste and fastest disintegration of the formulated tablets in oral cav ynareshcheruvolla@gmail.comResearch412014Tapentadol,Superdisintegrants,Mass extrusion,Immediate release tablets Naresh C,Shahid Mohammad S,Niranjan Babu MDepartment of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati-517561, Andhra Pradesh, India,Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati-517561, Andhra Pradesh, India,Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati-517561, Andhra Pradesh, India