24A REVIEW ON BREAK-BONE FEVERDengue fever also known as break-bone fever is an infectious tropical disease caused by the dengue virus. In a small proportion of cases the disease develops into the life-threatening dengue hemorrhagic fever, resulting in bleeding, low levels of blood platelets and blood plasma leakage, or into dengue shock syndrome, where dangerously low blood pressure occurs. Dengue is transmitted by several species of mosquito within the genus Aedes, principally A. aegypti. The virus has four different types; infection with one type usually gives lifelong immunity to that type, but only short-term immunity to the others. Subsequent infection with a different type increases the risk of severe complications. This review discussed on historical, diagnosis and management of denguebala.hospira@gmail.comReview312013Dengue,Break-bone fever,Symptoms,Diagnosis,TherapyG.Balammal,T.Sunil Kumar ReddyKrishna Teja Pharmacy College, Chadalawada Nagar, Tirupati-517605, Andhra Pradesh, India,Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India