20FORMULATION AND EVALUATION OF EXTENDED RELEASE MATIX TABLETS OF QUETIAPINE FUMARATE TABLETSThe main objective of the present work was to develop extended release matrix tablets of Quetiapine fumarate using different polymers viz. Carbopol, glyceryl behenate and vegetable oil. Varying ratios of drug and polymer like were selected for the study. After fixing the ratio of drug and polymer for control the release of drug up to desired time, the release rates were modulated by combination of two different rates controlling material and triple mixture of two different rate controlling material. The coating was done by Ethylcellulose as a film former and opadry yellow as coloring agent. After evaluation of physical properties of tablet, the in vitro release study was performed in 0.1 N HCl pH 1.2 for 2 hrs and in phosphate buffer pH 6.2 upto remaining hours. The effect of polymer concentration and polymer blend concentration were studied. Dissolution data was analyzed by Higuchi and Korsmeyer peppas. It was observed that matrix tablets contained polymer blend of carbopol 971p and 974p were successfully extended the release of drug up to 24 hrs. Among all the formulations, Quetiapine Fumarate Extended matrix tablets F006 which contains carbopol release the drug which follows Zero order kinetics, and the release profile of formulation of Quetiapine Fumarate Extended release matrix tablets of F006 was comparable with marketed product. Stability studies (40±2ºC/75±5%RH) for 3 months indicated that Quetiapine fumarate was stable in the matrix tabletsmohammedkhaja12@gmail.comResearch312013Extended release matrix tablets,Quetiapine FumarateMohd Khaja Pasha,G.Velrajan,V.Balasubramaniam,B.Dayakar,B.ShivakumarDepartment of Pharmacy, Smt.Sarojini Ramulamma College of Pharmacy, Mahabub Nagar – 509001, A.P, India,Department of Pharmacy, Smt.Sarojini Ramulamma College of Pharmacy, Mahabub Nagar – 509001, A.P, India,Department of Pharmacy, Smt.Sarojini Ramulamma College of Pharmacy, Mahabub Nagar – 509001, A.P, India,Department of Pharmacy, Smt.Sarojini Ramulamma College of Pharmacy, Mahabub Nagar – 509001, A.P, India,Department of Pharmacy, Smt.Sarojini Ramulamma College of Pharmacy, Mahabub Nagar – 509001, A.P, India