19FORMULATION AND EVALUATION OF EMTRICITABINE AND TENOFOVIR DISPROXIL FUMARATE IMMEDIATE RELEASE TABLETSEmtricitabine and Tenofovir Disproxil Fumarate belong to class of anti-retroviral drugs known as nucleotide analogue reverse transcriptase inhibitors. The main objective of the present study is to formulate and evaluate an immediate release tablet of Emtricitabine and Tenofovir Disproxil Fumarate using different disintegrants. Pre formulation studies were performed prior to compression. The tablets were compressed using microcrystalline cellulose, crospovidone, starch, PVP k30, Aerosil and were used for coating the tablets. The fabricated tablets were evaluated for various micrometric properties like bulk density, tapped density, compressibility index, Hausner’s ratio, angle of repose and post compression characteristics like thickness, hardness, friability, disintegration time and drug release. Crospovidone is found to be the better disintegrant when compared to starch in the formulation of immediate release tablets of Emtricitabine and Tenofovir Disproxil Fumarate. Compared to the wet granulation with PVP k30 as binder was found to be the best method of choice for formulation of these tablets. The absorbance of Emtricitabine and Tenofovir Disproxil Fumarate were screened in the UV region and the maximum absorbance was found to be 282 nm and 258nm respectively and this was used for UV analysis. The results of the present study indicates that, the prepared tablets of Emtricitabine and Tenofovir Disproxil Fumarate could perform therapeutically, with improved efficacy and better patient compliance like that of the marketed product.shiva.baddur@gmail.comResearch312013Emtricitabine,Tenofovir Disproxil Fumarate,Immediate release tabletsB.Shivakumar,V.Balasubramaniam, Sumayya Samreen,G.Velrajan,Mohd Khaja PashaDepartment of Pharmacy, Smt.Sarojini Ramulamma College of Pharmacy, Mahabub Nagar – 509001, A.P, India,Department of Pharmacy, Smt.Sarojini Ramulamma College of Pharmacy, Mahabub Nagar – 509001, A.P, India,Department of Pharmacy, Smt.Sarojini Ramulamma College of Pharmacy, Mahabub Nagar – 509001, A.P, India,Department of Pharmacy, Smt.Sarojini Ramulamma College of Pharmacy, Mahabub Nagar – 509001, A.P, India,Department of Pharmacy, Smt.Sarojini Ramulamma College of Pharmacy, Mahabub Nagar – 509001, A.P, India