129FORMULATION AND EVALUATION OF ANTIMICROBIAL HERBAL OINTMENTS FROM METHANOLIC EXTRACT OF ARGYREIA IMBRICATA (ROTH) SANTAPAU & PATELThe goal of the current investigation was to assess the antibacterial efficacy of an ointment made from methanolic Argyreia imbricata extracts (Roth). The Argyreia imbricata dried plant components were extracted with methanol using the Soxhlet technique. The extracts were tested for phytochemicals, pH, homogeneity, spreadability, tube extrudability, stability, and antibacterial activity before being used to make ointment. Escherichia coli and S. aureus were used to test the manufactured ointments' efficacy, and well-plate techniques were used to test the in vitro antibacterial activity of ointments made from plant extracts. By contrasting the findings of the zone of inhibition of the conventional ointments, the most effective ointments were identified (Ciprofloxacin). Both Staphylococcus aureus and E. coli have showed good action against prepared formulations, and it was discovered that the F1&F2 formulation of Argyreia imbricata ointments was exhibiting a greater zone of inhibition than the normal. It can also be used as a potential dosage form for clinical applications. The outcomes support the plant's usage in traditional medicineseba.pharm@gmail.comResearch1222022Argyrei imbricata,Staphylococcus aureus,EscherichiaV.Sebastin,Chaithanya A P,Deepika Pradeep, Deeshma.K,Fathimath Shaima, Noyal Shaji.EDepartment of Pharmaceutical Chemistry, Malik Deenar College of Pharmacy, Kasaragod-671321, Kerala, India,Department of Pharmaceutical Chemistry, Malik Deenar College of Pharmacy, Kasaragod-671321, Kerala, India,Department of Pharmaceutical Chemistry, Malik Deenar College of Pharmacy, Kasaragod-671321, Kerala, India,Department of Pharmaceutical Chemistry, Malik Deenar College of Pharmacy, Kasaragod-671321, Kerala, India,Department of Pharmaceutical Chemistry, Malik Deenar College of Pharmacy, Kasaragod-671321, Kerala, India