<?xml version="1.0" encoding="UTF-8"?><Articles><Article><id>100</id><JournalTitle>FORMULATION & DEVELOPMENT OF GLIPIZIDE FAST DISSOLVING TABLETS USING A NATURAL GUM AS SUPER DISINTEGRANT</JournalTitle><Abstract>The objective of the present research work is to develop a fast dissolving tablet of Glipizide with a view to provide
rapid control over high blood sugar levels and also to increase the bioavailability. For this purpose natural fenugreek gum was
selected as a super disintegrating agent which also possess antidiabetic activity. Owing to its antidiabetic property the
fenugreek gum not only acts as super disintegrant but also provides better control over blood sugar levels in combination with
glipizide. The method used was UV Spectrophotometric method was used for estimation of glipizide. The Rheological studies
indicated that the 1% w/v gum dispersions of Fenugreek gum in water had a gel like consistency. Direct compression technique
was employed for the formulation because it was easy to fabricate & all the excipients complied with this technique. In vitro
dissolution study results revealed that there was a significant rise in the release rate with the increment in the concentration of
the disintegrating agents. The drug release from all the formulations ascertained first order kinetics.</Abstract><Email>manivannanbiotech@gmail.com</Email><articletype>Research</articletype><volume>7</volume><issue>1</issue><year>2017</year><keyword>Fast dissolving tablets,Glipizide,Fenugreek Gum,UV Spectrophotometric method,Direct compression technique,In vitro dissolution</keyword><AUTHORS>Ramakotaiah M,B. Venkateswarlu naik,G.Prasanthi,G. Jhansi rani,K. Vijaya kumari,V. Srinivasa rao</AUTHORS><afflication>M.A.M. College of Pharmacy, Kesanupalli, Narasaraopet, Guntur (Dist), Andhra Pradesh, India.,M.A.M. College of Pharmacy, Kesanupalli, Narasaraopet, Guntur (Dist), Andhra Pradesh, India.,M.A.M. College of Pharmacy, Kesanupalli, Narasaraopet, Guntur (Dist), Andhra Pradesh, India.,M.A.M. College of Pharmacy, Kesanupalli, Narasaraopet, Guntur (Dist), Andhra Pradesh, India.,M.A.M. College of Pharmacy, Kesanupalli, Narasaraopet, Guntur (Dist), Andhra Pradesh, India.,M.A.M. College of Pharmacy, Kesanupalli, Narasaraopet, Guntur (Dist), Andhra Pradesh, India.</afflication></Article></Articles>